β-alanine has been used in food and pharmaceutical industries. Although Escherichia coli Nissle 1917 (EcN) is generally considered safe and engineered as living therapeutics, engineering EcN for producing industrial metabolites has rarely been explored. Here, by protein and metabolic engineering, Ec …
Apr 1, 2021 · Escherichia coli Nissle 1917 (EcN) is an endotoxin-free probiotic in the treatment of gastrointestinal diseases. However, two cryptic plasmids are stable in EcN causing metabolic burden, which limits its application in genetic engineering.
Background: The probiotic bacterial strain Escherichia coli Nissle 1917 (EcN) is used for the treatment of ulcerative colitis (UC), diarrhea and constipation. Its beneficial effects in the treatment of UC have been demonstrated in several controlled clinical studies; however, the mechanism of action on the cellular level is still not completely clear. Jan 1, 2017 · Escherichia coli strain Nissle 1917 (EcN) is a remarkable probiotic bacterium, first described by Alfred Nissle in 1916/17. As the active component of Mutaflor, EcN has been well researched over decades but detailed mechanisms by which EcN confers its probiotic effects are still elusive.
Studies have shown that EcN may be therapeutically effective in a variety of conditions such as ulcerative colitis, diarrhoea and chronic constipation. The E. coli strain Nissle 1917 is characterised by a number of features that set it aside from the rest of its family members. As a potent probiotic, it can work to promote digestive health.
Nov 29, 2021 · Engineered strains of probiotic Escherichia coli Nissle 1917 have been used to generate promising results as a treatment of phenylketonuria and hyperammonemia. However, despite recent progress, it remains challenging to engineer microbes with predictable phenotypes in the dynamic and complex environments of mammalian hosts. Indeed, the degree
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